Abstract
Fundamental and clinical studies were performed on aztreonam (AZT), a new antibiotic with single β-lactam ring, with the following results.
1. Following intravenous drip infusion of 1g, transfer of AZT to the internal genital organs was found to be good. Transfer of AZT to exudate of pelvic dead space was also good.
2. AZT was given to 6 cases, who had gynecological or obstetrical infectious disease. AZT was effective in the 5 cases out of 6, although it showed high MIC against bacteria isolated from the effective cases.
3. The above results demonstrated that AZT was a safe and effective drug.
