CLINICAL EVALUATION OF TMS-19-Q·GC TABLET ON SUPERFICIAL SUPPURATIVE DISEASE

A COMPARATIVE DOUBLE BLIND STUDY WITH MIDECAMYCIN

Abstract

Clinical efficacy and safety of TMS-19-Q·GC tablet (TMS), a new macrolide preparation, were compared with those of midecamycin (MDM) in superficial suppurative skin and soft tissue infections.
The study was made by the double-blind controled trial at the dosage of daily 600 mg in TMS group and 1,200 mg in MDM group.
Total 218 cases (106 in TMS, 112 in MDM) were analyzed and the final global improvement rating were 82.1% in TMS and 83.9% in MDM.
The clinical effectiveness of TMS was favorable and significantly different from MDM in the aged patients (≥60 years old) and the patients infected with susceptible strains (MIC≤3.13) of Staphylococcus aureus. TMS is prepared with a specific formulation to make the absorption easer in the patients with lower acidity of gastric juice, and the faborable effect of TMS is considered to be a contribution of the devise in older patients.
Slight adverse reactions were observed at 5.0% (6 cases) in TMS and 2.4% (3 cases) in MDM.
In conclusion, TMS at the daily half dose of MDM is as effective as MDM in superficial suppurative skin and soft tissue infections.