PHARMACOKINETIC STUDIES ON AZTREONAM IN THE LATE PREGNANCY OF SHEEP AND HUMAN

Abstract

The transplacental passage of single intravenous doses of aztreonam (AZT), 1g or 2g, was examined in 7 sheep and 14 women in late pregnancy, respectively and the obtained data were analyzed by a two-compartment model. The obtained results were summarized as follows.
1. After single 2g intravenous doses were given to pregnant sheep, the mean peak level of AZT in maternal blood was 83.79μg/ml and the half-life of the β-phase was 1.525 hours.
2. After single 1g intravenous doses were administered to pregnant women, the mean peak level of AZT in blood was 102.62μg/ml and the half-life of β-phase was 2.128 hours. The peak levels in umbilical venous blood and amniotic fluid were 14.43μg/ml and 11.86μg/ml, respectively.