Abstract
In 5 patients with respiratory tract infections, concentrations of cefotetan (CTT) in serum and sputum after 1 hour intravenous administration of 2 g of CTT to each patient were investigated, and following results were obtained.
1. Serum levels of CTT
The mean peak level of CTT was 232. 0± 16. 2μ g/ml immediately after the 1 hour drip infusion, then declined gradually and was 48. 0± 8. 8μ g/ml after 6 hours.
2. Sputum levels of CTT
Mean sputum levels of CTT were 2. 15± 0. 19μ g/ml from 2 to 4 hours after the administration and 2. 19± 0. 18μ g/ml from 4 to 6 hours.
3. Clinical evaluation of CTT
Clinical effects were excellent in 1 case, good in 3 cases and poor in 1 case. No side effects were observed.
