Imipenem/Cilastatin sodiumの産婦人科領域における基礎的・臨床的検討

畑瀬 哲郎; 河野 勝一; 深川 良二; 平井 ひろみ; 大蔵 尚文; 赤木 隆博; 綱脇 現; 加藤 俊

doi:10.11553/antibiotics1968b.39.1612

FUNDAMENTAL AND CLINICAL STUDIES ON IMIPENEM/CILASTATIN SODIUM IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

TETSURO HATASE, KATSUICHI KAWANO, RYOUJI FUKAGAWA, HIROMI HIRAI, NAOFUMI OHOKURA, TAKAHIRO AKAGI, AKITSU TSUNAWAKI, TOSHI KATO

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 6 Pages 1612-1619

DOI https://doi.org/10.11553/antibiotics1968b.39.1612

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Abstract

Fundamental and clinical studies on imipenem/cilastatin sodium (MK-0787/MK-0791) were carried out and the results obtained were summarized below.
1. The transfer of MK-0787/MK-0791 into female genital organ tissues was found to be satisfactory.
2. The transfer of MK-0787/MK-0791 into umbilical arterial blood, umbilical venous blood and amniotic fluid was relatively good.
3. A dose of 1,000mg/1,000mg perday of MK-0787/MK-0791 was given to each of 6 gynecology patients for 5-22 days and satisfactory clinical effect was obtained in 5 patients out of 6 patients.
No notable side effects or abnormal laboratory findings were observed except for a moderate in elevation in S-GOT/S-GPT in 1 case.

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