STUDIES ON THE METABOLIC FATE OF ISEPAMICIN SULFATE (HAPA-B)

V. PLASMA CONCENTRATIONS OF HAPA-B IN DOGS AFTER MULTIPLE ADMINISTRATIONS

Abstract

Plasma concentrations after a single or multiple intramuscular administrations of isepamicin sulfate (HAPA-B) at dose levels of 6.25, 25 and 100mg/kg to male and female dogs were measured by microbiological assay, and were also compared with those of amikacin at dose levels of 25 and 100mg/kg.
Shapes of plasma concentration curves after multiple administrations of HAPA-B were very similar to those after single administrations at all dosage levels tested.
On the other hand, the shape of plasma concentration curve after multiple administration ofamikacin at 100mg/kg was markedly different from that after a single administration.