PROPHYLACTIC EFFECTS OF A COMBINED USE OF A CEPHEM ANTIBIOTIC, LATAMOXEF, AND TOBRAMYCIN ON POSTOPERATIVE INFECTION IN OBSTETRICS AND GYNECOLOGY

Abstract

To prevent postoperative infection in obstetric gynecology, latamoxef (LMOX) and tobramycin (TOB) were intravenously administered to 81 patients at daily doses of 2 g and 120 mg, respectively, for 5 postoperative days, and the preventive effect of the combined drugs on postoperative infection were evaluated in terms of the clinical effects and safety.
1. The fever index was low as a whole; 3.38±2.30 degree hours in patients receiving simple panhysterectomy (n=61), 3.21±3.84 degree hours in those given cesarean section (n=12), and 3.53±2.78 degree hours in those given other surgical procedures (n=8).
2. There were no abnormalities in hematological findings or liver and kidney functions 14 days after the surgery. PIVKA-II was observed in 3 of 32 patients 14 days after the operation, at a rate of 9.4%.
3. Except mild diarrhea which was observed in 7 of the 81 patients (8.6%) in 4 to 6 days after the operation, no subjective or objective side effects or postoperative complications were observed.
The combined use of LMOX and TOB seems useful for preventing postoperative infection in obstetrics and gynecology in terms of its efficacy and safety.