1988 Volume 41 Issue 3 Pages 225-235
Ceftriaxone (CTRX) was clinically evaluated and its pharmacokinetics studied in neonates. The results obtained are summarized below.
1. Blood levels of CTRX at 8 to 12 hours after intravenous injection with a single dose of 10 to 20mg/kg ranged from 14.9 to 32.8μg/ml, while T 1/2 ranged from 8.2 to 24.8 hours.
2. Blood levels of CTRX at 11 hours after the completion of drip infusion which lasted one hour with a dose level 10 to 20mg/kg, ranged from 10.6 to 25.0μg/ml, while T 1/2 was 5.4 to 22.8 hours.
3. Multiple intravenous administrations were given to premature infants, but blood levels did not show evidence of drug accumulation.
4. Urinary excretion in 6 hours after an intravenous injection or a drip infusion with 10-20mg/kg of CTRX ranged from 13.8 to 58.5% of the dosage.
5. The subjects in this study were 9 neonates with suspected sepsis, pneumonia, Staphylococcus epidermidis or Staphylococcus aureus infections (sepsis, staphylococcal scalded skin syndrome, pneumonia), acute bronchitis or meconium aspiration syndrome. Efficacies CTRX were excellent or good in all these cases administered in a daily dose of 19.5 to 41.6mg/kg for 4 to 11 days
6. No general side effects or abnormalities were observed in blood count, or hepatic or renal function.
