EFFECTS OF CEFTRIAXONE ON INFECTIONS DURING THE PERINATAL PERIOD
1988 Volume 41 Issue 3 Pages 306-311
Details
1988 Volume 41 Issue 3 Pages 306-311
Ceftriaxone (CTRX) was studied for its efficacy and safety in 8 cases of infection during the perinatal period; 6 before, and 2 after delivery. The results obtained are recognized as follows:
1. CTRX was administered by intravenous drip infusion at a daily dose between 2 and 4g for 2 to 10 days (a total dose: 4 to 20g) each of 8 cases of infections during the perinatal period; 3 of amniotic fluid infection and 1 each of intrauterine infection, puerperal fever, puerperal wound infection, appendicitis and pyelonephritis. CTRX was evaluated to be very effective in 3, effective in 3 and ineffective in 2, with an efficacy rate of 75%(6/8).
2. Two strains of Enterococcus faecalis and 1 each of Pseudomonas cepacia and Streptococcus intermedius were isolated. All of them were eradicated by the CTRX treatment bacteriologically.
3. No adverse reactions were observed subjectively or objectively. A slight transient elevation of GOT, GPT and Al-P was observed in 1 case. No abnormal sign was observed in neonates.
