新規ピリドンカルボン酸系抗菌剤Lomenoxacin ((±)-1-Ethyl-6, 8-difiuoro-1, 4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quirlolinecarboxylic acid hydrochloride) の抗菌作用

小池田 聡; 岡部 博之; 柴田 仁美; 長谷 哲; 中西 義信; 桶崎 英一; 加藤 日出男; 正宗 行人

doi:10.11553/antibiotics1968b.42.193

BACTERICIDAL ACTION OF LOMEFLOXACIN A NEW PYRIDONECARBOXYLIC ACID DERIVATIVE

SATOSHI KOIKEDA, HIROYUKI OKABE, HITOMI SHIBATA, TETSU HASE, NOBUYOSHI NAKANISHI, EIICHI OKEZAKI, HIDEO KATO, YUKITO MASAMUNE

Author information

SATOSHI KOIKEDA
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
HIROYUKI OKABE
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
HITOMI SHIBATA
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
TETSU HASE
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
NOBUYOSHI NAKANISHI
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
EIICHI OKEZAKI
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
Central Research Laboratory, Hokuriku Seiyaku Co. Ltd., Fukui
HIDEO KATO
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University
Central Research Laboratory, Hokuriku Seiyaku Co. Ltd., Fukui
YUKITO MASAMUNE
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kanazawa University

JOURNAL FREE ACCESS

1989 Volume 42 Issue 1 Pages 193-199

DOI https://doi.org/10.11553/antibiotics1968b.42.193

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Abstract

Lomefloxacin (NY-198) [(±)-1-ethyl-6, 8-difluoro-1, 4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride] strongly inhibited the growths of not only Gramnegative Escherichia coli but Gram-positive Staphylococcus aureus.
In vivo and in vitro experiments showed deoxyribonucleic acid (DNA) synthesis was specifically inhibited by this drug in E. coli.

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