高齢者呼吸器感染症におけるCefoperazoneの臨床評価, 特に腎機能に及ぼす影響の検討

谷本 普一; 鈴木 俊光; 佐藤 武材; 広田 佳行; 永井 英明; 米田 良蔵; 松田 美彦; 両角 克朗; 河野 典博; 栗山 喬之; 中沢 浩亮; 藤枝 一雄; 森成 元; 加藤 明彦; 深山 牧子; 稲松 孝思; 中田 紘一郎; 中森 祥隆; 原 茂子; 折津 愈; 池田 大忠; 大久保 隆男

doi:10.11553/antibiotics1968b.42.1199

CLINICAL EFFECTIVENESS OF CEFOPERAZONE FOR RESPIRATORY INFECTIONS OF ELDERLY PATIENTS, FOCUSING ON ITS SAFETY ON RENAL FUNCTION

HIROICHI TANIMOTO, TOSHIMITSU SUZUKI, TAKEKI SATO, YOSHIYUKI HIROTA, HIDEAKI NAGAI, RYOZO YONEDA, YOSHIHIKO MATSUDA, KATSUROU MOROZUMI, NORIHIRO KOHNO, TAKAYUKI KURIYAMA, HIROAKI NAKAZAWA, KAZUO FUJIEDA, HAJIME MORINARI, AKIHIKO KATO, MAKIKO FUKAYAMA, TAKASHI INAMATSU, KOICHIRO NAKADA, YOSHITAKA NAKAMORI, SHIGEKO HARA, MASARU ORITSU, HIROTADA IKEDA, TAKAO OKUBO

Author information

HIROICHI TANIMOTO
The Forth Department of Internal Medicine, Jikei University School of Medicine
TOSHIMITSU SUZUKI
Respiratory Unit, Showa General Hospital
TAKEKI SATO
Department of Respiratory Diseases, The Second Tokyo National Hospital
YOSHIYUKI HIROTA
Department of Respiratory Diseases, The Second Tokyo National Hospital
HIDEAKI NAGAI
Department of Respiratory Diseases, Tokyo National Chest Hospital
RYOZO YONEDA
Department of Respiratory Diseases, Tokyo National Chest Hospital
YOSHIHIKO MATSUDA
Department of Respiratory Diseases, Nakano National Chest Hospital
KATSUROU MOROZUMI
Department of Respiratory Diseases, Nakano National Chest Hospital
NORIHIRO KOHNO
Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
TAKAYUKI KURIYAMA
Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
HIROAKI NAKAZAWA
Internal Medicine, Tokyo Kyosai Hospital
KAZUO FUJIEDA
Department of Respiratory Diseases, Tokyo Teishin Hospital
HAJIME MORINARI
Department of Respiratory Diseases, Tokyo Teishin Hospital
AKIHIKO KATO
Department of Infectious Diseases, Tokyo Metropolitan Geriatric Hospital
MAKIKO FUKAYAMA
Department of Infectious Diseases, Tokyo Metropolitan Geriatric Hospital
TAKASHI INAMATSU
Department of Infectious Diseases, Tokyo Metropolitan Geriatric Hospital
KOICHIRO NAKADA
Department of Respiratory Diseases, Toranomon Hospital
YOSHITAKA NAKAMORI
Department of Respiratory Diseases, Toranomon Hospital
SHIGEKO HARA
Kidney Center, Toranomon Hospital
MASARU ORITSU
Department of Respiratory Diseases, Japan Red Cross Medical Center
HIROTADA IKEDA
The First Department of Internal Medicine, School of Medicine, Yokohama City University
TAKAO OKUBO
The First Department of Internal Medicine, School of Medicine, Yokohama City University

JOURNAL FREE ACCESS

1989 Volume 42 Issue 5 Pages 1199-1207

DOI https://doi.org/10.11553/antibiotics1968b.42.1199

Details

Abstract

Clinical effectiveness of cefoperazone (CPZ) was studied for 46 elderly patients with respiratory infections.
1. Clinical efficacy rate of CPZ was 80.6% (29/36).
2. Adverse reactions occurred in 2 patients as systemic rush and fever. Laboratoryabnormalities were observed in 5 patients. These included elevation of transaminase value.
3. The serum concentration of CPZ at 12 hours after administration of 2 g CPZ was not reflected in creatinine clearance and total bilirubin, and those 2 values appearedto have little effects on CPZ excretion.
4. The administration of CPZ at 4g/day for less than 3 weeks had no effects on therenal function.
As a result of this study, CPZ was found to have little undesirable effect on renal functions and to be a useful drug for the treatment of respiratory infections in elderly patients.

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