PHARMACOKINETIC AND CLINICAL STUDIES ON AZTREONAM IN PERINATAL PERIOD

Abstract

Pharmacokinetic and clinical studies were carried out on aztreonam (AZT), a monobactam antibiotic with a high activity against Gram-negative bacteria.
The results obtained are summarized as follows:
1. Following 2g bolus intravenous injection, transfers of AZT to umbilical cord serum and amniotic fluid were found to be satisfactory. AZT level in amniotic fluid was higher than μg/ml at 40 minutes after administration and it was at 3.7 μg/ml in 23.5 hours.
2. In the treatment of 9 patients with perinatal infections, clinical efficacies of AZT were judged excellent in 3 cases and good in 6 cases.
3. No side effects and abnormal laboratory findings due to the drug were observed in any case.
These results indicate that AZT may be a useful antibiotic for the treatment of perinatal infections.