1991 Volume 44 Issue 1 Pages 9-13
We investigated the postoperative bile excretion and serum concentration of cefuzonam (CZON) in 6 cholecystectomized patients with postsurgical biliary drainage. CZON was administered intravenously by infusion at a dose of 1.0g immediately following the operation. Serum and bile concentrations of CZON were determined on the day of the operation and the second day after the operation. The following results were obtained.
1. Serum concentrations of CZON were at their highest levels at 30 minutes after administration of CZON. Levels were 45.8±13.8μg/ml on the day of the operation and 60.9±12.2μg/mlon the second postsurgical day.
2. Bile concentration peaked 1 hour after administration (4,083±1,427μg/ml on the day of the operation and 4,376±630μg/ml on the second postsurgical day). In paticular, bileconcentrations of CZON at 6 hours (259±140μg/ml and 154±23μg/ml) exceeded MIC80 of CZONagainst Gram-negative bacteria except for Pseudomonas aerugionsa.
3. Serum and bile concentrations were higher on the second postsurgical day than on the day of the operation, but the differences between these 2 days were not significant.
These results have indicated that CZON is a useful drug with excellent bile excretion following cholecystectomy, and that bile concentrations of CZON are maintained at high levels for 6 hours after intravenous administration.
