The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
CLINICAL EFFICACY OF CEFPIROME AGAINST VARIOUS INFECTIOUS DISEASES IN CHILDREN
HIROSI WAKIGUCHI, MIKIYA FUJIEDA, AKIHIKO MAEDA, YOHSEI SHIMAZAKI, NAOFUMI OHISHI, SHINJI KIDO, TOMOKI TAKECHI, KOHJI TAKEDA, HARUKO MAEDA, HIDEO MORITA, TAKANOBU KURASHIGE
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1991 Volume 44 Issue 2 Pages 241-245

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Abstract
The clinical efficacy and the pharmacokinetics of cefpirome (CPR, HR 810), a new semisynthetic cephalosporin derivative, were investigated in children with various infectious diseases.
CPR showed high blood peak levels, relatively long half-life and high levels in urine.
Excellent clinical efficacy was obtained in 2/3 cases with pneumonia, 3/4 cases with upper respiratory infection, 2/2 cases with cutaneous and soft tissue infection and 1/1 case with urinary tract infection. The overall efficacy rate was 80%.
No clinical adverse effects were observed while slightly elevated GPT and GOT, decreased platelet were detected in 4 cases without clinical problems.
CPR should be an useful and safe drug in treating infectious diseases in children.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series B

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