ANTHRACYCLINE ANTIBIOTIC 2-HYDROXYACLACINOMYCINS

II. PRODUCTION OF 2-HYDROXYACLACINOMYCINS A AND B BY A NEW RECOMBINANT STRAIN AND THEIR ANTITUMOR ACTIVITIES

Abstract

Anthracycline antibiotics 2-hydroxyaclacinomycins A and B were isolated and purified from the culure broth of a recombinant strain which was produced by protoplast fusion of two aclacinomycinbrocked mutants. 2-Hydroxyaclacinomycin B is a new compound for which chemical structure and the biologial activity in vitro were determined. 2-Hydroxyaclacinomycins had a stronger antitumor activity against murine leukemic L1210 cells in mice than the parent antibiotic aclacinomycins.