Abstract
Effects of sulbactam/cefoperazone (SBT/CPZ) on the hostparasite relationship were studied using an established mouse macrophage cell line.Since SBT inactivates some types of β-lactamase strongly, a combination of SBT with CPZ show smarked antibacterial activities against the bacteria producing β-lactamases.In addition, sub-MIC levels of SBT/CPZ made Escherichia coli more susceptible to bactericidal activity of macrophage.
This study provides evidence that SBT/CPZ works in partnership with host defense mechanism against bacterial infections in clinical situations.
