難治性呼吸器感染症に対するAspoxicillin・Ceftazidime併用の臨床的検討

山木 健市; 鈴木 隆二郎; 滝 文男; 高木 健三; 佐竹 辰夫; 水野 勝之; 馬場 研二; 相原 博; 森 雅典; 山田 健司; 石川 正彦; 原 通廣; 松本 修一; 荒井 孝; 今井 昌利; 角田 俊昭; 田野 正夫; 岩田 勝; 野坂 博行; 笹本 基秀; 古井 秀彦; 伊藤 光保; 宮武 博之; 権田 秀雄; 野田 康信

doi:10.11553/antibiotics1968b.45.1282

A CLINICAL STUDY OF COMBINED THERAPY OF ASPOXICILLIN AND CEFTAZIDIME ON INTRACTABLE RESPIRATORY INFECTIONS

KENICHI YAMAKI, RYUJIRO SUZUKI, FUMIO TAKI, KENZO TAKAGI, TATSUO SATAKE, KATSUYUKI MIZUNO, KENJI BABA, HIROSHI AIHARA, MASANORI MORI, KENJI YAMADA, MASAHIKO ISHIKAWA, MICHIHIRO HARA, SHUICHI MATSUMOTO, TAKASHI ARAI, MASATOSHI IMAI, TOSHIAKI KAKUTA, MASAO TANO, MASARU IWATA, HIROYUKI NOSAKA, MOTOHIDE SASAMOTO, HIDEHIKO FURUI, MITSUYASU ITO, HIROYUKI MIYATAKE, HIDEO GONDA, YASUNOBU NODA

Author information

KENICHI YAMAKI
2nd Department of Internal Medicine, Nagoya University School of Medicine
RYUJIRO SUZUKI
2nd Department of Internal Medicine, Nagoya University School of Medicine
FUMIO TAKI
2nd Department of Internal Medicine, Nagoya University School of Medicine
KENZO TAKAGI
2nd Department of Internal Medicine, Nagoya University School of Medicine
TATSUO SATAKE
2nd Department of Internal Medicine, Nagoya University School of Medicine
KATSUYUKI MIZUNO
3rd Department of Internal Medicine, Aichi Medical College
KENJI BABA
3rd Department of Internal Medicine, Aichi Medical College
HIROSHI AIHARA
3rd Department of Internal Medicine, Aichi Medical College
MASANORI MORI
3rd Department of Internal Medicine, Aichi Medical College
KENJI YAMADA
3rd Department of Internal Medicine, Aichi Medical College
MASAHIKO ISHIKAWA
3rd Department of Internal Medicine, Aichi Medical College
MICHIHIRO HARA
Department of Respiratory Disease, Ogaki Municipal Hospital
SHUICHI MATSUMOTO
Department of Respiratory Disease, Ogaki Municipal Hospital
TAKASHI ARAI
Department of Internal Medicine, Toki Municipal Hospital
MASATOSHI IMAI
Department of Internal Medicine, Ichinomiya Municipal Hospital
TOSHIAKI KAKUTA
Department of Internal Medicine, Ichinomiya Municipal Hospital
MASAO TANO
Department of Internal Medicine, Kariya General Hospital
MASARU IWATA
Department of Internal Medicine, Kariya General Hospital
HIROYUKI NOSAKA
Department of Internal Medicine, Gifu Koseiren Showa Hospital
MOTOHIDE SASAMOTO
Department of Respiratory Disease, National Higashi Nagoya Hospital
HIDEHIKO FURUI
Department of Respiratory Disease, National Higashi Nagoya Hospital
MITSUYASU ITO
Department of Internal Medicine, Handa Municipal Hospital
HIROYUKI MIYATAKE
Department of Internal Medicine, Handa Municipal Hospital
HIDEO GONDA
Department of Internal Medicine, Toyohashi Municipal Hospital
YASUNOBU NODA
Department of Internal Medicine, Toyohashi Municipal Hospital

JOURNAL FREE ACCESS

1992 Volume 45 Issue 10 Pages 1282-1294

DOI https://doi.org/10.11553/antibiotics1968b.45.1282

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Abstract

Both aspoxicillin (ASPC) and ceftazidime (CAZ) were administerted together to 55 patients with intractable respiratory tract infections. ASPC and CAZ were administerted at daily doses of 4g and 2 to 4g, respectively. Clinical effects were excellent in 11 cases, good in 33, fair in 7 and poor in 4, thus the efficacy rate was 80.0%. Bacteriologically, identified organisms were eradicated in 14 cases out of 21, decreased in 3, exchanged in 2 and unchanged in 2. The eradication rate was 76.2%. As a side effect, diarrhea was found in only one case, and abnormal laboratory test values were observed in 4 cases. However, these adverse reactions were not severe, therefore it was possible to continue the chemotherapy.
These results indicate that the combination antimicrobial chemotherapy of ASPC and CAZ is effective against intractable respiratory tract infections.

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