1992 Volume 45 Issue 2 Pages 181-187
The effectiveness and the safety of panipenem/betamipron, new antibiotics of the carbapenems for burn infections, were studied and the following results were obtained:
1. The preparation, 0.5g/0.5g, was administered by intravenous drip infusion twice a day to 11 cases of patients with burn infections. In 10 cases for which clinical effects were evaluable, results were rated as “excellent” in 2 cases, “good” in 2 cases and “fair” in 6 cases, with an efficacy rate of 40%.
2. Penetration to the affected tissue was studied in 2 cases. The tissue level of panipenem was 0.20μg/g immediately after the end of drip infusion and 6.86μg/g 60 minutes thereafter.
3. As for the safety, a slight increase in GOT, GPT and Al-P was noted in 1 case; a slight increase in GPT, NAG and β2MG was found in 1 case; and a slight increase in GOT, GPT, Al-P and LAP was noted in 1 case, as abnormal variations in laboratory test results.
