CLINICAL PHARMACOLOGY AND EFFICACY OF MEROPENEM
1992 Volume 45 Issue 6 Pages 727-733
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1992 Volume 45 Issue 6 Pages 727-733
We studied a newly developed carbapenem, meropenem (MEPM), and obtained the following results.
1. Pharmacokinetics of MEPM in pediatrics was examined in 3 patients. MEPM was injected intravenously at a dose of 16-22 mg/kg by drip infusion for 30 minutes, and its concentrations in serum and urine were determined using bioassay. The average peak value of serum levels of MEPM was 38.4μg/ml and T1/2β of MEPM was 1.26 hours. The urinary recoverly rate for the first 6 hours after administration was 65.6%.
2. Clinical evaluations of MEPM in pediatrics were done in 14 patients with ages ranging, 1 month to 14 years, with various bacterial infections. Excellent or good clinical responses were observed in all patients, and bacteriological eradication were obtained in 7 out of 8 cases. No serious side effects were observed in any cases, but 2 showed mild and transient GOT, GPT elevations.
