CLNICAL EVALUATION OF A NEW CEPHEM S-1108 IN INFANTS AND CHILDREN
1993 Volume 46 Issue 12 Pages 1075-1082
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1993 Volume 46 Issue 12 Pages 1075-1082
A clinical study in children has been performed on S-1108, a newly developed cephem antibiotic. S-1108 was given orally to 30 patients, at doses between 8 and 12mg/kg/day in 3 divided doses for 2 to 10 days. Clinical evaluations were made on 26 patients consisting of 12 patients of pharyngitis, 5 of tonsillitis and of impetigo, one each of bronchitis, cystitis, lymphadenitis and cellulitis. Overall clinical effects were excellent in 10, good in 15, fair in 1 with an efficacy rate of 96%. As to adverse reactions, mild diarrhea (2 patients) and transients elevation of transaminases (one patient) were observed.
These data suggest that S-1108 is a useful oral antibiotic for the treatment of bacterial infections in children.
