1993 Volume 46 Issue 2 Pages 154-158
The transferability of vancomycin (VCM) to cerebrospinal fluid (CSF) was studied employing rabbits with experimental meningitis caused by Staphylococcus aureus.
VCM was administered intravenously for 30 minutes at a dose level of 30mg/kg. Serum concentration reached a maximum of 75 3.80μg/ml (mean±S. E.) at the completion of administration (i. e., 30 minutes) and CSF concentration reached a maximum of 2.4±0.39μg/ml at 60 minutes.
Pharmacokinetic parameters calculated from this concentration-time curve were as follows: Cmax (CSF/Serum) 3.21%, AUC (CSF/Serum) 2.39% between 15 and 60 minutes, 3.99% between 15 and 120 minutes, and 4.40% between 15 and 150 minutes. T 1/2 for VCM in CSF: 143 minutes, T1/2 (CSF/Serum): 2.09.
Based on this investigation, VCM appears to be effective in the treatment of meningitis caused by MRSA (Methicillin-resistant S. aureus).
