BACTERICIDAL ACTIVITY OF ARBEKACIN AGAINST METHICILLINRESISTANT STAPHYLOCOCCUS A UREUS
COMPARISON WITH THAT OF VANCOMYCIN
1994 Volume 47 Issue 6 Pages 640-646
Details
1994 Volume 47 Issue 6 Pages 640-646
Bactericidal activity of arbekacin (ABK) against methicillin-resistantStaphylococcusa ureus(MRSA) was compared with that of vancomycin (VCM). MIC80, of VCM against 1,056 clinical isolates was 2μg/ml and not a single strain of those in of which MIC above 4μg/ml was detected. Whereas MIC80, of ABK against the isolates was 1μg/ml, but a few strains of which showed MIC of 8μg/ml or 16μg/mi.
A killing-curve study indicated that bactericidal activity of ABK was critically dependent on its concentrations. ABK, at higher concentrations, showed excellent killing effects against all the tested isolates, and the effects were superior to those of VCM because of following reasons; great reduction CFU was attained within short time incubation, and the effects were not remarkably influenced by different inoculum sizes of MRSA. At lower concentrations of ABK, between a half and four times MIC, the re-increaseo f CFU of MRSAw ith appearanceo f characteristics mall coloniesw as observed. Considering the concentration of ABK in usual dose, the significance of the re-growth should be carefully assessed. It showed be recommended that the peak concentration of ABK be elevated to higher level if adverse effects do not appear.
