1994 Volume 47 Issue 6 Pages 701-709
Combination effects were studied with arbekacin(ABK)and β-lactam antibiotics including imipenem/cilastatin(IPM/CS), flomoxef(FMOX), and cefotiam(CTM)for bactericidal activities, post-antibiotic effects(PAE's)and bactericidal activities of β-lactam antibiotics after removal of ABK using methicillin-resistant Staphylococcus aureus (MRSA)strain1936. The following results were obtained.
1. When ABK was administered in combination with IPM/CS, FMOX or CTM against MRSA strain 1936, low FIC index was not obtained.
2. Higher bactericidal activity was observed when ABK was given before β-lactam than when β-lactam was given before ABK.
3. Combination of ABK and each of β-lactam antibiotic led a longer PAE than ABK alone.
4. When each β-lactam antibiotic was administered after a treatment and removal of ABK, greater bactericidal activity and growth inhibition were observed than when administered each β-lactam alone.A
These findings basically demonstrated that ABK was effectively bactericidal against MRSA when administered in combination with β-lactam antibiotic such as IPM/CS, FMOX or CTM, even when the FIC index did not indicate a favorable effect.
