COMBINED THERAPY WITH ARBEKACIN AND FOSFOMYCIN FOR METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS

KENJI KONO; SEIJI TAKEDA; ICHIRO TATARA; KIKUO ARAKAWA; HIROAKI TANAKA; SHUNJI MIYAKE; HIROMICHI MINAMIKAWA; HIROSUKE HOSHINO; MIKIO SATO; FUMITADA HATTORI; KOZABURO KAWAHIRA

doi:10.11553/antibiotics1968b.47.798

COMBINED THERAPY WITH ARBEKACIN AND FOSFOMYCIN FOR METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS

KENJI KONO, SEIJI TAKEDA, ICHIRO TATARA, KIKUO ARAKAWA, HIROAKI TANAKA, SHUNJI MIYAKE, HIROMICHI MINAMIKAWA, HIROSUKE HOSHINO, MIKIO SATO, FUMITADA HATTORI, KOZABURO KAWAHIRA

Author information

KENJI KONO
The Second Department of Internal Medicine, Fukuoka University, School of Medicine
SEIJI TAKEDA
The Second Department of Internal Medicine, Fukuoka University, School of Medicine
ICHIRO TATARA
The Second Department of Internal Medicine, Fukuoka University, School of Medicine
KIKUO ARAKAWA
The Second Department of Internal Medicine, Fukuoka University, School of Medicine
HIROAKI TANAKA
Egashira Hospital
SHUNJI MIYAKE
Hakujuji Hospital
HIROMICHI MINAMIKAWA
Minamikawa Hospital
HIROSUKE HOSHINO
Murakami Karindo Hospital
MIKIO SATO
Murakami Karindo Hospital
FUMITADA HATTORI
Nagao Hospital
KOZABURO KAWAHIRA
Kawanami Hospital

JOURNAL FREE ACCESS

1994 Volume 47 Issue 6 Pages 798-803

DOI https://doi.org/10.11553/antibiotics1968b.47.798

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Abstract

We examined the clinical efficacy of a combination of arbekacin and fosfomycin in the treatment of various methicillin-resistant Staphylococcus aureus (MRSA) infections. The combination ofarbekacin plus fosfomycin displayed 65.4% (17/26) clinical efficacy and 65.4% (17/26) bacteriological efficacy. This combination thus appeared to be an effective regimen for the treatment of MRSA infections. However, its bacteriological efficacy against concomitant Pseudomonas aeruginosa strains was only 16.7% (1/6). In addition, in 4 episodes of superinfection involving P. aeruginosa strains developed during the combination therapy.

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