Abstract
After an intravenous drip infusion of 1g or 2g of ceftriaxone (CTRX), its concentrations in serum and tissue were determined using the bioassay for 18 surgical patients with chronic paranasal sinusitis.
1. The serum levels observed at 75-105, 135-165, 195-225 minutes after an intravenous drip infusion of 1g, averaged 98±38, 92±13 and 73±13μg/ml, respectively.
2. The tissue levels at 75-105, 135-165, 195-225 minutes after an intravenous drip infusion of 1 g, averaged 27±13, 27±7 and 25±9μg/g.
3. CTRX appears to be a useful drug for the treatment of chronic paranasal sinusitis.
