The First Department of Internal Medicine, Kurume University School of Medicine and Affiliated Hospitals
The First Department of Internal Medicine, Kurume University School of Medicine and Affiliated Hospitals
The First Department of Internal Medicine, Kurume University School of Medicine and Affiliated Hospitals
The First Department of Internal Medicine, Kurume University School of Medicine and Affiliated Hospitals
The First Department of Internal Medicine, Kurume University School of Medicine and Affiliated Hospitals
The First Department of Internal Medicine, Kurume University School of Medicine and Affiliated Hospitals
College of Medical Technology, Hokkaido University, School of Medicine
Department of Respiratory Diseases, Sapporo Hospital of Hokkaido Railway Company
Department of Respiratory Diseases, Sapporo Hospital of Hokkaido Railway Company
The Third Department of Internal Medicine, Iwate Medical University
The Third Department of Internal Medicine, Iwate Medical University
The Third Department of Internal Medicine, Iwate Medical University
The Third Department of Internal Medicine, Iwate Medical University
Department of Respiratory Diseases, Iwate Prefectural Central Hospital
Department of Respiratory Diseases, Iwate Prefectural Central Hospital
The First Department of Internal Medicine, Yamagata University School of Medicine
The First Department of Internal Medicine, Yamagata University School of Medicine
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Tohoku University and Affiliated Hospital
Department of Cardiovascular System, Sendai Red-Cross Hospital
Department of Internal Medicine, Research Institute for Chest Diseases and Cancer (Institute of Development, Aging and Cancer), Tohoku University and Affiliated Hospitals
Department of Internal Medicine, Research Institute for Chest Diseases and Cancer (Institute of Development, Aging and Cancer), Tohoku University and Affiliated Hospitals
Department of Internal Medicine, Research Institute for Chest Diseases and Cancer (Institute of Development, Aging and Cancer), Tohoku University and Affiliated Hospitals
Department of Internal Medicine, Research Institute for Chest Diseases and Cancer (Institute of Development, Aging and Cancer), Tohoku University and Affiliated Hospitals
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Affiliated Hospital
Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Affiliated Hospital
Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Affiliated Hospital
Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Affiliated Hospital
Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Affiliated Hospital
The First Department of Internal Medicine, Kyorin University School of Medicine
The First Department of Internal Medicine, Kyorin University School of Medicine
The First Department of Internal Medicine, Kyorin University School of Medicine
Department of Respiratory Diseases, St. Luke's International Hospital
Department of Respiratory Diseases, National Medical Center Hospital
Department of Respiratory Diseases, National Medical Center Hospital
Department of Respiratory Diseases, National Tokyo Hospital
Department of Respiratory Diseases, National Tokyo Hospital
Department of Respiratory Diseases, National Tokyo Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Institute of Medical Science, St. Marianna University
Institute of Medical Science, St. Marianna University
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
The First Department of Internal Medicine, Yokohama City University School of Medicine
The First Department of Internal Medicine, Yokohama City University School of Medicine
The First Department of Internal Medicine, Yokohama City University School of Medicine
The First Department of Internal Medicine, Yokohama City University School of Medicine
The First Department of Internal Medicine, Yokohama City University School of Medicine
Department of Internal Medicine, Kanagawa Prefecture Midwives and Nurses
Department of Internal Medicine, Kanagawa Prefecture Midwives and Nurses
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
The Second Department of Internal Medicine, Niigata University, School of Medicine
The Second Department of Internal Medicine, Niigata University, School of Medicine
The Second Department of Internal Medicine, Niigata University, School of Medicine
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Toyama Prefectural Central Hospital
The Second Department of Internal Medicine, Hamamatsu University School of Medicine
The Second Department of Internal Medicine, Hamamatsu University School of Medicine
Department of Internal Medicine II, Nagoya University School of Medicine
Department of Internal Medicine II, Nagoya University School of Medicine
The First Department of Internal Medicine, School of Medicine, Nagoya City University and Affiliated Hospitals
The First Department of Internal Medicine, School of Medicine, Nagoya City University and Affiliated Hospitals
The First Department of Internal Medicine, School of Medicine, Nagoya City University and Affiliated Hospitals
The First Department of Internal Medicine, School of Medicine, Nagoya City University and Affiliated Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Affiliated Hospital
The First Department of Internal Medicine, Osaka Medical University
The First Department of Internal Medicine, Osaka Medical University
The First Department of Internal Medicine, Osaka Medical University
The Second Department of Internal Medicine, Nara Medical University
The Second Department of Internal Medicine, Nara Medical University
The Second Department of Internal Medicine, Nara Medical University
The Third Department of Internal Medicine, Hyogo Medical University
The Third Department of Internal Medicine, Hyogo Medical University
The Third Department of Internal Medicine, Hyogo Medical University
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
The Second Department of Internal Medicine, Kawasaki Medical School, Kawasaki Hospital
The Second Department of Internal Medicine, Kawasaki Medical School, Kawasaki Hospital
The Second Department of Internal Medicine, Hiroshima University School of Medicine
The Second Department of Internal Medicine, Hiroshima University School of Medicine
The Third Department of Internal Medicine, Tottori University School of Medicine
The Third Department of Internal Medicine, Tottori University School of Medicine
Department of Internal Medicine, Kitakyushu Municipal Medical Center Hospital
Department of Internal Medicine, Kitakyushu Municipal Medical Center Hospital
Department of Internal Medicine, Kitakyushu Municipal Medical Center Hospital
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Affiliated Hospitals
The First Department of Internal Medicine, School of Medicine, Kumamoto University
The First Department of Internal Medicine, School of Medicine, Kumamoto University
The First Department of Internal Medicine, School of Medicine, Kumamoto University
Department of Internal Medicine, Kumamoto Municipal Hospital
Department of Internal Medicine, Kumamoto Municipal Hospital
Department of Internal Medicine, Kumamoto Municipal Hospital
The Second Department of Internal Medicine, Oita Medical University and Affiliated Hospital
The Second Department of Internal Medicine, Oita Medical University and Affiliated Hospital
The Second Department of Internal Medicine, Oita Medical University and Affiliated Hospital
The Second Department of Internal Medicine, Oita Medical University and Affiliated Hospital
The First Department of Internal Medicine, School of Medicine, Ryukyu University
The First Department of Internal Medicine, School of Medicine, Ryukyu University
The First Department of Internal Medicine, School of Medicine, Ryukyu University
The First Department of Internal Medicine, School of Medicine, Ryukyu University
Department of Pharmacology, School of Medicine, Ehime University
Section of Studies, Tokyo Clinical Research Center
1995 Volume 48 Issue 4 Pages 482-513
(compatible with EndNote, Reference Manager, ProCite, RefWorks)
(compatible with BibDesk, LaTeX)
The efficacy, safety and usefulness were evaluated for a combined antibiotic tazobactam/ piperacillin (TAZ/PIPC) consisting of a new β-lactamase inhibitor, tazobactam (TAZ), and a broad spectrum penicillin antibiotic, piperacillin (PIPC), in chronic respiratory tract infections with PIPC as the control in a multi-institutional comparative study.
The drugs used were a preparation containing 0.5 g of TAZ and 2.0 g of PIPC per vial (TAZ/PIPC group) and a preparation containing 2.0 g of (PIPC group). The drugs were intravenously injected one vial at a time twice a day for 14 days as a rule.
The following results were obtained:
1. Clinical effect
There was no significant difference between TAZ/PIPC (86% or 76/88) and PIPC (81% or 69/85).
2. Bacteriological effect
There was no significant difference between TAZ/PIPC (93% or 42/45) and PIPC (88% or 36/41) in terms of bacterial eradication rates. In 34 patients with β-lactamase-producing pyogenic bacteria, there was no significant difference between TAZ/PIPC (77% or 10/13) and PIPC (88% or 15/17).
3. Degrees of improvement in clinical symptoms, signs and laboratory findings
The TAZ/PIPC group was likely to show reductions in fever and the amount of sputum soon after administration.
4. Side effects
Incidences of side effects were 7% (7/96) in the TAZ/PIPC group and 3% (3/89) in the PIPC group, showing no significant difference between the two groups. The main symptoms were allergic reaction and gastrointestinal symptoms.
5. Abnormal clinical laboratory test values
The incidence was 17% (15/89) in the TAZ/PIPC group and 21% (18/87) in the PIPC group. The main symptoms were eosinophilia and hepatic dysfunction, and most of these symptoms were mild.
6. Usefulness
The usefulness rates in the TAZ/PIPC group were 80% (71/89) and 78% (66/85) in the PIPC group, showing no significant difference.
Thus, TAZ/PIPC exhibited excellent clinical effects and presented no troubles with safety. When comprehensively evaluated, TAZ/PIPC appears to be a very useful drug for the treatment of chronic respiratory tract infections.