Abstract
Postantibiotic effects (PAE's) of macrolide antibiotics were determined for Staphylococcus aureus and Enterococcus faecalis using viable counting and Bioscreen C method and the two methods were compared.
No major differences between the two methods were observed. The Bioscreen C method was less laborious than the viable counting.
The durations of PAE for S. aureus following exposures to erythromycin (EM), josamycin (JM) and rokitamycin (RKM) for 2 hours at twice the MICs were in ranges of 0.85 to 1.45, 2.36 to 3.48 and 1.93 to 5.45 hours, respectively.
A definite PAE of 1.0 to 5.8 hou rs was also observed in E. faecalis strains exposed for 2 hours to EM, JM and RKM at twice the MICs.
