The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
STUDY OF CLINICALLY ISOLATED NEW QUINOLONES-RESISTANT HAEMOPHILUS INFLUENZAE PART 1
YUMIKO SUZUKIMASAMI KOGUCHISETSUKO TANAKASHIGEMI FUKAYAMARIKA ISHIHARAKOICHI DEGUCHISEIJI ODAYUTAKA NAKANETORAO FUKUMOTO
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1995 Volume 48 Issue 8 Pages 1026-1032

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Abstract
A study was done to determine susceptibilities of Haemophilus influenzae that were obtained in our laboratory in 1994 to new quinolones (NQ) and other drugs.
The results were as follows;
1. Among the 300 isolates, the detection frequency of NQ-resistant strains was 8.7%(26 strains), including isolates from chronic lower respiratory tract infections (22 strains) and those from middle meatus of nose (2 strains), etc. NQ-resistant strains were not isolated from children.
2. The cross resistance was studied for different NQs against NQ-resistant strains. Clavulanic acid/amoxicillin, cefteram, cefpodoxime, cefditoren, cefodizime (CDZM) and cefpirome showed strong antimicrobial activities against NQ-resistant strains. MIC90 of CEPs against all isolated strains including NQ-resistant strains and β-lactamase producers was low. And the MIC90 of CDZM was ≤0.025μg/ml, which was the lowest among all the antibiotics tested.
3. We found 47 strains (15.7%) of β-lactamase producers among the 300 isolates, the frequency of β-lactamase producing strains was high among strains obtained from children.
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© Japan Antibiotics Research Association
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