Abstract
The in vitro antibacterial activity of biapenem (BIPM), a new carbapenem antibiotic, was compared withthose of imipenem (IPM), panipenem (PAPM), meropenem (MEPM), ceftazidime (CAZ) and piperacillin (PIPC) against 280 isolates of 9 respiratory pathogens.
The MIC90s of biapenem (BIPM) for methicillin-susceptible Stophylococcus aureus (MSSA), methicillinresistant Staphylococcus aureus (MRSA), streptococcus pneumoniae, Moraxella catarrhalis, Pseudomonasaeruginosa, and Haemophilus influenzae were 0.12, 32, 0.25, 0.06, 4and8μg/ml, respectively.
In comparison with other antibiotics, the activity of biapenem (BIPM) for P.aeruginosa was as potent asmeropenem (MEPM), but for H.influenzae it was slightly less than those of other antibiotics, and for otherrespiratory pathogens it was as potent as those of other antibiotics.
The MIC90s of biapenem (BIPM) for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae andserratia marcescens were 0.06, 1, 1, 0.5μg/ml, respectively, and which were equal to or somewhat lower thanthose of other antibiotics.
Biapenem (BIPM) showed strong activity against Gram-positive and Gram-negative pathogens, especiallyP.aeruginosa in general.
Based on these results, biapenem (BIPM) is seemed to be highly useful antibiotic for the treatment of respiratory infections with several organism.
