Abstract
The results of the semi-annual nationwide surveillance of antimicrobial susceptibilities, conducted by the Japanese Ministry of Health and Welfare during the period of January 1993 to July 1995, were analyzed for typical Gram-negative bacilli in the purpose of provision of an index for antimicrobial selection.
During these 3 years, Escherichia coli, Citrobacter freundii, Enterobacter aerogenes and Proteus mirabilisshowed slightly increasing tendency in susceptibility to fosfomycin (FOM) and Citrobacter freundii, Klebsiellapneumoniae and Enterobacter aerogenes showed slightly increasing tendency to minocycline (MINO). WhileHaemophilus influenzae and Haemophilus parainfluenzae showed slightly decreasing tendency to cefmetazole (CMZ). However, these annual changes were almost negligible.
Generally, these microorganisms showed relatively good susceptibilities, every year, to the principal antimicrobialagents being approved for use against Gram-negative bacilli. However, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens and Pseudomonas aeruginosa showed tendencies of decresed susceptibilityto some of the antimicrobial agents.
On the other hand, sulfamethoxazole-trimethoprim (ST), CMZ, latamoxef (LMOX), gentamicin (GM) andamikacin (AMK) showed good activities against some of the Gram-negative bacilli towhich no indications areapproved.
In conclusion, bedside the identification of the causative microorganisms and the performance of antimicrobialsusceptibility testing, such analyses (graphics of susceptibility tendency ofclinical isolates to variety ofantimicrobial agents) could be used as an index for selection of antimicrobial agents, when emergent and urgent selection of antimicrobial agents is necessary.
