The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST 5,180 CLINICAL ISOLATES OBTAINED FROM 26 MEDICAL INSTITUTIONS DURING 1998 IN JAPAN
KEIZO YAMAGUCHI, SHUICHI MIYAZAKI, FUSAKO KASHITANI, MORIHIRO IWATA, MAKOTO KANDA, YOSHIKO TSUJIO, NAOKI WATANABE, NOBUYUKI UEHARA, MITSUOMI KAIMORI, CHIZUKO KAWAMURA, TOSHIO NISAWATAIRA, HIROMI TASHIRO, KYOKO UENO, MINORU YASUJIMA, CHUICHI ITOH, TAKESHI YOSHIDA, SHUNKOH TOYOSHIMA, JUN KATOH, MASAKO KUDOH, TADAO FUNATO, MITSUO KAKU, NOBUKO SATO, YOSHIHIKO SAITO, KEIKO ISHII, JUN OKADA, YOKO TAZAWA, JUN IGARI, TOYOKO OGURI, YOSHITSUGU IINUMA, SHIOMI ISHIGO, SHIGEHARU KAWAHARA, KIYOHARU YAMANAKA, TOSHIHARU MATSUSHIMA, YOSHIHITO NIKI, NAOYUKI MIYASHITA, MASAO KUWABARA, TOSHIHARU HONGO, KIYOSHI NEGAYAMA, MASAHIDE TAKII, MASAMI ISHII, JUNKO ONO, TOHRU TAKADA, NORIYUKI MURAKAMI, JUTARO TADANO, ZENZO NAGASAWA, SHIMERU KAMIHIRA, YOSHITSUGU MIYAZAKI, KEIICHI NAKAGAWA, MASAHIRO TAIRA, ITARU TAMAKI, YUKO MATSUDOU, NOBUCHIKA KUSANO, ISAMU NAKASONE
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2000 Volume 53 Issue 6 Pages 387-408

J-STAGE : antibiotics1968b 53 9 pp.C4
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Abstract
The surveillance study was conducted to determine the antimicrobial activity of fluoroquinolones (ofloxacin, levofloxacin, ciprofloxacin, tosufloxacin) and other 20 antimicrobial agents against 5,180 clinical isolates obtained from 26 medical institutions during 1998 in Japan.
The resistance to fluoroquinolones was remarkable in Enterococci, methicillin-resistant stapylococci and Pseudomonas aeruginosa from UTI. However, many of the common pathogens such as Streptococcus pneumoniae including penicillin-resistant isolates, methicillin-susceptible Stahylococcus aureus, Moraxella catarrhalis, the family of Enterobacteriaceae, Haemophilus influenzae including ampicillin-resistant isolates have been kept to be susceptible to fluoroquinolones. About 90% of P. aeruginosa isolates from RTI were susceptible to fluoroquinolones.
In conclusion, the results from this surveillance study suggest that fluoroquinolones are useful in the treatment of various bacterial infections including respiratory infections.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series B

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