Studies on the Pyridomycin Production. IV Metabolic Studies on Streptomyces Pyridomyceticus

Abstract

In the previous report¹⁾, the author presented a complex medium suitable for pyridomycin production and described that 40-hours shaken-cultured broth of the pyridomycin-producing strain contained four kinds of substances promoting pyridomycin production. Three of them were ascertained to be serine, tryptophan, and kynurenine. It was suggested that pyridomycin would be produced through tryptophan and kynurenine. The author also described that pyridomycin was produced in synthetic media from glucose, gluconic acid, and arabinose. These results suggested that, when glucose was metabolized through gluconic acid-pentose, pyridomycin was produced. These points were further studied and presented in this paper.