Antitumor Effect of Pluramycin A on Experimental Animal Tumors Studies on Antitumor Products of Streptomyces, II

Abstract

In the previous paper⁽¹⁾, the author reported antitumor effect of actinomycin J on Ehrlich carcinoma, mouse sarcoma 180 and Yoshida rat sarcoma. Actinomycin J and pluramycin A, both have strong antibacterial activities and they are reddish pigments of streptomyces. According to a report of Umezawa and others^(2,3) pluramycin A exhibited antitumor activity on Ehrlich carcinoma much stronger than that of actinomycin J. Comparative studies on antitumor effects of these antibiotics made by the same researcher was considered to be helpful for the evaluation of their antitumor activities. This report describes results of experiments testing antitumor effects of pluramycin A on three kinds of experimental animal tumors described above.