1958 Volume 11 Issue 4 Pages 150-155
In 1956, it was reported by Aiso and his coworkers that a crude powder obtained from culture broth of a new streptomyces strain indicated a clear antitumor activity against Ehrlich cancer cells. It was named Gancidin1).
In its further purification study of gancidin we could isolate several basic and neutral fractions from the crude complex.
But in antitumor animal test of these isolated fractions, any clear antitumor activity as reported by Aiso, et al. formerly was not recognized, though a certain fraction indicated an extraordinary high activity against microbes and some other fraction prolongation effect on survival periods of tumor bearing animals.
