1959 Volume 12 Issue 6 Pages 323-327
Cross resistance appears to be one of the most interesting problems in the points of bacterial genetics as well as of the chemotherapy of tuberculosis. The authors have once concerned with the problem of cross resistance with reference to kanamycin resistance in Mycobacterium tuberculosis and reported that viomycin-resistant mutants of the organism are less sensitive to kanamycin and mutation frequency to kanamycin resistance in viomycin-resistant mutants is higher than that in sensitive nonmutants as well as mutants resistant to various antituberculous drugs1),2). Following the previous studies, the present paper will concern with the remaining problem of cross resistance, that is, sensitivity of kanamycin-resistant mutants to other antituberculous drugs and mutation frequencies to other antituberculous drugs in kanamycin-resistant mutants of M. tuberculosis.
