1960 Volume 13 Issue 3 Pages 177-179
It is well known that kanamycin has a remarkable effect on Mycobacteria, in vitro and in vivo. However, its toxicity similar to streptomycin may become a target of criticism in the course of prolonged administration tn tuberculosis practice. Therefore, lowering of its toxicity with the same or higher activity is very desirable.
Recently, H. Umezawa et al. reported the biological characteristics of new derivatives of kanamycin prepared by S. Umezawa et al. These were named tetrasodium-kanamycin-tetra-N-methanesulfonate (KMD-1) and disodium-kanamycin-di-N-methanesulfonate sulfate (KMD-3), respectively, and have been confirmed on their lower toxicity to laboratory animals than the kanamycin1,2).
In the present paper, observations on the bacteriostatic activities in vitro against human type tubercle bacilli, H2 strain and therapeutic effect on mice tuberculosis of these derivatives were reported.