A New Antibiotic, Amidinomycin [N-(2’-Amidinoethyl)-3-Aminocyclopentanecarboxamide] Produced by a Streptomyces

Abstract

A Streptomyces isolated from a soil sample collected at Shizuoka Prefecture produced an antibiotic inhibiting B. subtilis in a cylinder plate and this active substance was isolated and the structure, N-(2’-amidinoethyl)-3-aminocyclopentanecarboxamide, was determined. This antibiotic showed an incomplete inhibition against spore-forming bacteria and had relatively strong toxicity to mice. This paper presents characters of Streptomyces producing the antibiotic and processes for production and isolation. Structural studies will be reported in another paper¹⁾.