Studies on Antibiotic Actinomycetes. I On Streptomyces Producing A New Antibiotic Tubermycin

Abstract

New antibituberculous antibiotics, tubermycins A and B were reported in 1958 by K. Isono et al.¹⁾ Both substances were monobasic acids having the formulas C₁₂H₁₆N₂O₂ and C₁₃H₃N₂O₂ respectively. The former was proved to be identical with phenazine α-carboxylic acid, and the latter its analogous compound. The strain No. 1755 producing tubermycins A and B seemed to be a new species of streptomyces and was named Streptomyces misakiensis. The present paper deals with morphological and cultural studies on Streptomyces misakiensis (No. 1755 strain) from the view point of taxonomy.