Studies on the Action of Antibiotics on Bacterial Metabolism. VII Tetracyclines and Bacterial Respiration

Abstract

There is various informations on the inhibitory action of oxytetracycline and chlortetracycline upon the bacterial metabolism. The following reactions are reported to be inhibited by oxytetracycline and chlortetracycline; the respiration system^1–5), the oxidative phosphorylation system^6-8), the formation of adaptive enzyme⁹⁾, the metabolism of nucleic acid^10–13), the oxidation of amino acid^2,14), the reduction of nitrite^15–16) and the activity of metal-protein 17).

The experiments presented in this paper, are concerned with the effect of oxytetracycline and chlortetracycline on the aerobic carbohydrate metabolism by the sensitive bacteria of coli-aerogenes.