Supplementary Pharmacological Data on Variotin, An Antifungal Antibiotic

Abstract

Variotion, a new antifungal antibiotic clinically applied, has been improved by the research group of Nippon Kayaku Company. In the previous paper⁽¹⁾, the present authors reported on the pharmacology of variotin, especially on the skin irritability and effect on the autonomic nervous system. It was found that variotin caused no noticeable local reaction of skin by topical application, with almost no effect on hemogram and body weight. On the other hand, variotin was found to have a cholinergic action to the autonomic nervous system, the stress of which is somewhat lowered by a consecutive application. It was revealed also that variotin has an anesthetic action on muscle or anti-barium action at higher levels. It was concluded from such pharmacological action that the consecutive application of variotin causes less toxic effect, because patients are under the stress of infection.

Similar investigations with newly obtained variotin indicated a lowering of toxicity and an alleviation of pharmacological effect. The comparative study of variotin 1 (50 mg/ml) reported previously and variotin 2 (200 mg/ml) obtained newly is described in the present paper.