1962 Volume 15 Issue 1 Pages 1-6
A strain, Streptomyces No. 7548, was isolated in 1954 from a sample of soil collected in Mishima, Osaka Prefecture. The antibiotic produced by the strain was active chiefly against Gram-positive bacteria, and though extracted as a chemically acid substance, it showed strong activity in basic conditions, and th erefore it was assumed to be a physiologically basic substance. At that time, chlortetracycline, luteomycin and the like were known as physiologically acid substances having acid or amphoteric nature, but as there was found no report on physiologically basic antibiotics, the peculiar properties of the present antibiotic invited the authors’ interest. Thereafter investigation was made on the mycological properties and cultural conditions of the strain and on the extraction and purification of the antibiotic. And from its physiological and physicochemical properties, the antibiotic was assumed to be different from any of known antibiotics, so it was named glumamycin1).
