1964 Volume 17 Issue 3 Pages 96-99
Culture filtrates of actinomycetes have been screened for the inhibitory activity against growth and glycolysis of Yoshida rat sarcoma cells. From culture filtrates of a strain thus selected, a new antibiotic was isolated and named formycin. As reported in another paper, the formycin-producing strain was classified by Hamada and Okami1) to Nocardia interforma n. sp.
Formycin shows inhibition against Ehrlich carcinoma, Yoshida rat sarcoma cells and HeLa cells, and also against Xanthomonas oryzae in an ordinary medium and Mycobacterium 607 in a synthetic medium. It shows no inhibition of glycolysis, though this inhibition was observed in the culture filtrate. This paper presents the isolation and characterization of formycin.
