Toyocamycin, A New Anti-Candida Antibiotics

Abstract

During a systematic search for new antibiotics produced by Streptomyces, in which Candida albicans was employed as test organism, a crystalline antibiotic substance has been isolated from a previously undescribed species of Streptomyces No. 278 which inhibits only Candida species. Since the physical appearance of this organism and its growth characteristics on various media were not in accordance with the description of any Streptomyces species described in the standard references, Bergey⁽¹⁾ and Waksman and Lechevalier⁽²⁾, it was given the name Streptomyces toyocaensis. The description of the organism will be reported elsewhere. The following paper contains an account of production, isolation, physical and chemical properties and activities of the new antibiotic for which the name toyocamycin is proposed.