On the Effects of Histamine Injection on the Liver of Rats
1959 Volume 16 Issue 1 Pages 45-51
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1959 Volume 16 Issue 1 Pages 45-51
The liver of the rats was studied histologically after the subcutaneous injections of histamine dihydrochloride daily 3mg for 69-470 days.
1. The liver is mostly of a cloudy very dark reddish colour, swells a little and is brittle, and then parenchymatous degeneration can be presumed.
2. Congestion in the hepatic sinusoids (73.3%) can be seen, and the blood vessels in GLISSON's capsule are mostly dilated.
3. Cloudy swelling (100%) and fatty degeneration (60%) of the liver cells are noted without regard to the injection-frequency, and necrosis of the cells (53.3%) is noted in the animals which were injected with histamine for more than 150 days.
4. Change in the size and of the form, or degeneration of the cell nuclei can be noted, but these are mostly related to the degeneration of the liver cell itself.
5. Groups of the unknown cells appear in the lobulus. The cells give a yellow or a light orange colour by the staining of haematoxylin and eosin. In this study, the authors could not investigate the origin of the cells.
