Abstract
In order to study the effects of the cortical hormone of the suprarenal glands on the secretory activity of the gastric peptic cells, hydrocortisone 1mg, 5mg, 10mg per 1kg of the animal's weight was injected subcutaneously 1 time, 5 times and 10 times and, on the other hand, hydrocortisone 10mg/kg or anthranilic acid 10mg/kg was injected for 5 days after the total extirpation of the suprarenal glands. The secretory activity of the gastric peptic cells in each experiment was compared and discussed with those obtained in case of normal animals. The results obtained can be summarized as follows.
1. It is obvious that the cortical hormone has some effect upon the secretory ability of the gastric peptic cells. The fact can be analyzed as in the following cases.
2. The regular and sure effect is to inhibit the discharge of the gastric hormone productin from the gastric surface cells, regardless of the dose injected. Accordingly, as a result of this effect, a small dose of the hormone seems to be inhibitory on the secretory activity of the peptic cells.
3. A large dose of the hormone inhibits the secretory activity of the peptic cells more remarkably than it inhibits the discharge of productin.
4. An intervening dose of the hormone has irregular effects in different cases, it sometimes actively promotes production of secretory granules in the peptic cells and sometimes vacuolization of the granules. The reason for this, it is assumed that the cortical hormone is not a direct stimulant of the secretory activity of the peptic cells but effective on it by the balance with some other substance.
5. As a result of the extirpation of the suprarenal glands and of the injection of 10mg/kg hydrocortisone or 10mg/kg anthranilic acid for 5 days after the extirpation, it is noticed that a promotive effect on the vacuolization of the peptic secretory granules seems to be peculiar to the cortical hormone in addition to its regular and sure effect on productin secretion.
