Histochemical Evaluation of NADP-dependent Glucose-6-Phosphate and Isocitrate Dehydrogenases in Steroid Producing Organs and Tumors

Abstract

Histochemical observations on NADP-dependent dehydrogenases, glucose-6-phosphate and isocitrate dehydrogenases, in steroid producing tissues under physiological and pathological conditions were carried out. The enzymatic activities were confined to the internal thecal cell and corpus luteum in ovaries, adrenal cortex and chorionic villi of placentas. In tumors originated from these organs, the enzymatic activities were variable in tumor cells irrespective of endocrinological features. The localization patterns and stainabilities among NADP-dependent dehydrogenases and 3β-ol dehydrogenase, generally showed parallel relations except for a few exception.