Unusual Tubular Inclusions in the Mitochondrial Matrix from Human Livers with Cholelithiasis

Abstract

Unusual tubular inclusions in the mitochondrial matrix of human hepatocytes were found in 7 out of 15 cases with cholelithiasis. These inclusions were composed of tubular structures which were about 50nm in diameter and varying in number. The wall of the individual tubules appeared to consist of about 10 tubular subunits with a diameter of about 5nm. Although some relationship between occurrence of these tubular inclusions and production of gallstones might be suggested, their origin and functional significance are unknown.