Abstract
The Islands of LANGERHANS in normal dogs were histo-cytologically observed, according to alterations of their age and food. And moreover the quantitative measuring of the islands of LANGERHANS were all cubically observed by serial sections. As its result, it was recognized that the islands of LANGERHANS are formed newly after birth, and most remarkably during the period from the end of lactation to delactation. This is presumed to have a relation not only to the growth of the pancreas, but to the alteration of food. The author classified the cells in the islands of LANGERHANS into six types chiefly by the vacuoles in the fine structures of the cells.
As the result of histo-cytological observation of the remaining pancreas after partial pancreatectomy, in the case of 1/2-resection, the islands of LANGERHANS were newly formed numerously from epithelium of pancreatic ducts on the 3rd day, and in the case of 4/5-pancreatectomy on the 2nd week. Then it was recognized that the forces of this compensational regeneration had been very rapid and vigorous, and more remarkable in the case where the tail part of pancreas was resected than in the head part, and the larger the sphere, the more the regeneration was vigorous.
On the 3rd or 4th day after 1/2-pancreatectomy, the external secretion of the pancreas was temporary decreased, but after about 5th day of the resection it gradually began to recover, and at the 2nd week, was very near to its control. But in the case of 4/5-pacreatectomy, the recovering forces appeared to be very slowly and weak.
