Abstract
Previously, FUJIE suggested the theory that histamine increases in blood during 1-1.5hrs. after a taking of diet, and it must be owing to a discharge of histamine from the gastric mucous membrane into blood. To prove his theory positively, the authors extracted histamine with alcohol (NAKAMURA's method) from liver, lung, kidney (which are closely connected with blood circulation), stomach and blood of rats, then histamine value of them were determined colorimetrically with SERA's diazo-reaction and the BECKMAN's spectrophotometer. The results obtained are indicated in 5 tables and in 5 figures.
In liver, lung and kidney, no special data could be obtained except their histamine values which may be considered much influenced by histamine contained in blood.
In stomach (stomach wall), however, very interesting phenomena were seen. The histamine values were highest in the starved condition and became lower after a taking of diet. The reverse was the case of the histamine in blood. It took place first an increase of histamine in blood and a decrease of it in stomach, then a decrease of histamine in blood and an increase of it in stomach. These facts indirectly verify the theory that the increase of histamine in blood after a taking of diet is due to the discharge of histamine from the stomach wall.
