Lipase-Catalyzed Enantioselective Hydrolysis of N-Protected Racemic Amino Acid Esters

Ken-ichi Kagawa; Sadaharu Nanba; Katsuhiro Kawashiro

doi:10.11491/apcche.2004.0.798.0

Asian Pacific Confederation of Chemical Engineers congress program and abstracts

Session ID : 3P-01-075

DOI https://doi.org/10.11491/apcche.2004.0.798.0

Conference information

Host: The Society of Chemical Engineers, Japan

Lipase-Catalyzed Enantioselective Hydrolysis of N-Protected Racemic Amino Acid Esters

Ken-ichi Kagawa, Sadaharu Nanba, Katsuhiro Kawashiro

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Keywords: lipase, optical resolution, unusual amino acid, enantioselectivity

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Porcine pancreatic lipase (PPL) hydrolyzed N-benzyloxycarbonyl (Z)-DL-amino acid esters enantioselectively to give optically pure Z-L-amino acids. Glyceryl (Gl) and carbamoylmethyl (Cam) esters of Z-amino acids were found to be applicable for optical resolution of various protein and unusual amino acids by PPL.

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